Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions
نویسندگان
چکیده
منابع مشابه
Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions
Understanding pharmacological target coverage is fundamental in drug discovery and development as it helps establish a sequence of research activities, from laboratory objectives to clinical doses. To this end, we evaluated the impact of tissue target concentration data on the level of confidence in tissue coverage predictions using a site of action (SoA) model for antibodies. By fitting the mo...
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ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2016
ISSN: 2163-8306,2163-8306
DOI: 10.1002/psp4.12126